English

Bienvenue dans le groupe de recherche Marsault.

L'objectif des travaux du groupe est de concevoir et synthétiser des molécules qui permettront de valider des cibles biologiques émergentes, afin d'identifier de nouvelles approches vers le médicament ou le diagnostique.

Notre recherche est interdisciplinaire, faisant intervenir des collaborations avec plusieurs groupes de recherche en pharmacologie, biologie, chimie, imagerie et médecine. Mon expérience dans le domaine s'appuie sur une formation initiale en chimie organique (BSc ESCOM, Université Pierre et Marie Curie; PhD McGill; postdoc Sherbrooke) suivie d'une dizaine d'années en milieu pharmaceutique (Sanofi Milan puis Néokimia/Tranzyme Pharma Sherbrooke).

book cover

Practical Medicinal Chemistry with Macrocyles

Édité par Éric Marsault et Mark Peterson

Macrocycles are medium to large ring compounds that offer medicinal chemists the benefits of both small molecules and biomolecules – oral bioavailability and extended surface areas, which possess great potential for difficult therapeutic targets. Because of this, there is now extensive interest in the use of macrocycles for drug discovery and raises the need for a handy guidebook about the basics and practices of working with them.

Including case studies of macrocyclic marketed drugs and macrocycles in drug development, Practical Medicinal Chemistry with Macrocycles offers a practical resource for those scientists developing new therapeutic agents. With chapters contributed from leading international figures involved in macrocyclic drug discovery efforts, the book is broken into four parts: challenges specific to macrocycles, classes of macrocycles and their potential in drug discovery, synthetic methods to make macrocycles, and case studies of macrocyclic marketed drugs and macrocycles in drug development.