Welcome to Marsault research group.

The goal of the group is to design and synthesize molecules to validate emerging biological targets, toward the identification of novel therapeutic and diagnostic agents. What fascinates me in medicinal chemistry is our unlimited ability to imagine new structures and optimize their properties for specific biological goals.

My expertise in the field relies on an initial training in organic chemistry (BSc ESCOM, Université Pierre et Marie Curie, Paris; PhD McGill University, Montreal; postdoc U. Sherbrooke), followed by ca 10 years in the pharmaceutical industry (Sanofi Milan and Néokimia/Tranzyme Pharma Sherbrooke).

book cover

Practical Medicinal Chemistry with Macrocyles

Edited par Éric Marsault and Mark Peterson

Macrocycles are medium to large ring compounds that offer medicinal chemists the benefits of both small molecules and biomolecules – oral bioavailability and extended surface areas, which possess great potential for difficult therapeutic targets. Because of this, there is now extensive interest in the use of macrocycles for drug discovery and raises the need for a handy guidebook about the basics and practices of working with them.

Including case studies of macrocyclic marketed drugs and macrocycles in drug development, Practical Medicinal Chemistry with Macrocycles offers a practical resource for those scientists developing new therapeutic agents. With chapters contributed from leading international figures involved in macrocyclic drug discovery efforts, the book is broken into four parts: challenges specific to macrocycles, classes of macrocycles and their potential in drug discovery, synthetic methods to make macrocycles, and case studies of macrocyclic marketed drugs and macrocycles in drug development.